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other antigen: type A persons have A antigen on their red cells and anti-B antibody in their serum; type B persons have B antigen on their red cells and anti-A antibody in their serum; type O persons do not have either antigen but have both antibodies in their serum; and type AB persons have both A and B antigens and form neither anti-A or anti-B antibodies in their serum. The I A and I B alleles, coding for glycosyl transferase enzymes, each cause a different modi cation to the terminal sugars of a mucopolysaccharide (H structure) found on the surface of red blood cells ( g. 2.13). They are codominant because both modi cations (antigens) are present in a heterozygote. In fact, whichever enzyme (product of the I A or I B allele) reaches the H structure rst will modify it. Once modi ed, the H structure will not respond to the other enzyme. Therefore, both A and B antigens will be produced in the heterozygote in roughly equal proportions. The i allele causes no change to the H structure: because of a mutation it produces a nonfunctioning enzyme. The i allele and its phenotype are recessive; the presence of the I A or I B allele, or both, c# print pdf without adobe How to Print a PDF programmatically without the Adobe Reader ...
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